NAMs Insight
New Safety Assessment Technology That Protects People and the Environment by Replacing Animal Testing
What are NAMs?
NAMs (New Approach Methodologies) are innovative scientific technologies that assess chemical safety using human cells and computer models without animal testing.
Traditional toxicity testing relied on animals like rats and rabbits, but new methods have emerged that are faster, more cost-effective, and ethically responsible.
How Does It Work?
Computer Prediction (In Silico)
AI-powered toxicity prediction
Organoids & Organ-on-a-Chip (In Vitro)
3D cell cultures and microchip experiments mimicking human tissues and organs
These methods deliver results that are more relevant to humans, faster, and more accurate.
Why Does It Matter?
NAMs is more than just a replacement for animal testing. It's a sustainable safety assessment framework that protects both people and the environment through more ethical and scientific approaches.
Regulatory agencies worldwide are actively adopting NAMs. In South Korea, it has been selected as one of the 100 key national agenda items and is gaining attention from the Ministry of Environment and Ministry of Food and Drug Safety as a future assessment technology.
NAMs: Safety Science for People and the Environment
Opening a new era of faster, more accurate chemical safety assessment without animal testing.
Global Regulatory Trends
Major regulatory agencies worldwide are transitioning to NAMs-based chemical assessment
European Union
Mandated alternatives to animal testing through REACH (Registration, Evaluation, Authorization and Restriction of Chemicals). ECHA is actively promoting NAMs adoption
United States
EPA and FDA announced a roadmap to phase out animal testing by 2035 and transition to a NAMs-centered assessment system
OECD
Developing international harmonized NAMs Test Guidelines (TG) and promoting FAIR (Findable, Accessible, Interoperable, Reusable) data principles
Why ChemBAI is Future-Proof
ChemBAI is a NAMs-specialized platform company designed at the intersection of regulatory evolution and scientific innovation. We provide explainable and regulatory-acceptable toxicity prediction solutions, not just AI.
Explainable AI (XAI)
ChemBAI's toxicity prediction models don't just provide results—they visually explain:
- Why the prediction was made
- Which pathways (AOP) are involved
This delivers the level of transparency regulators need for evidence-based decision-making.
NGRA Alignment
ChemBAI is designed to align with the Next Generation Risk Assessment (NGRA) framework, fully supporting the science-based evaluation processes regulators require.
- Integrates diverse NAMs techniques (QSAR, Read-Across, WoE, etc.)
- Links with real-world exposure scenarios
- Conducts proactive risk analysis for Safe-by-Design
FAIR Principles
ChemBAI's data is managed according to the internationally recognized FAIR principles:
- Findable
- Accessible
- Interoperable
- This structure ensures reliability and transparency for both research and regulatory applications.
Regulatory Ready
ToxBAI and ChemBAI NGRA are built from the ground up to be regulatory-ready:
- Compliant with OECD Test Guidelines (TG)
- Compatible with REACH and FDA submission formats A policy-responsive system ready for both regulatory assessments and corporate internal validation.
Safe-by-Design
ChemBAI supports a Safe-by-Design approach that considers safety from the earliest stages of product development.
- Prevents toxicity risks proactively
- Identifies safer alternative substances
- Develops eco-friendly product design strategies
From the Language of Research to the Language of Regulation and Industry
ChemBAI doesn't simply "adopt" NAMs-based technology—we've built the NAMs philosophy into the core operating principles of our company and platform.
Traditional Approach
- ❌Relies on animal testing (ethical and time issues)
- ❌Assessment takes months to years
- ❌High costs for personnel and experiments
- ❌Limited range of assessable chemicals
ChemBAI NAMs
- ✓AI-powered scientific toxicity prediction
- ✓Results available in minutes to hours
- ✓Assess more substances at lower cost
- ✓Scalable prediction for novel substances
ChemBAI, the NAMs Company
Designing a Safer Future with Data
- NAMs is no longer a technology of the future.
- It has already become the standard language of global regulatory science.
- ChemBAI is the digital toxicity assessment platform that makes this a reality through data and AI.